Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieBreast Cancer
CeRNA1Circ-Foxo3[Circular RNA]
miRNAmiR-433[miRNA]
CeRNA2Foxo3[mRNA]
Tissue/Cell lineMda-Mb-468 And Mda-Mb-231
SpecieHomo sapiens (human)
CitationOncogene 2016 Jul 28 35, 3919-31 doi:10.1038/onc.2015.460 PMID:26657152
Reference title
Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay
Functional description
We found that the transcripts of Foxo3 mRNA, Foxo3P and Foxo3 circular RNA were all targets of miR-22, miR-136*, miR-138, miR-149*, miR-433, miR-762, miR-3614–5p and miR-3622b–5p. Together, these mechanisms effectively promoted the translation of the Foxo3 mRNA.
Annotations
External Annotation for Circ-Foxo3 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
