Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieDiabetic Nephropathy
CeRNA1TUG1[LncRNA]
miRNAmiR-377[miRNA]
CeRNA2PPAR[mRNA]
Tissue/Cell lineSv40 Mes13
SpecieMus musculus (mouse)
CitationBiochem Biophys Res Commun 2017 Mar 11 484, 598-604 doi:10.1016/j.bbrc.2017.01.145 PMID:28137588
Reference title
Long noncoding RNA TUG1 alleviates extracellular matrix accumulation via mediating microRNA-377 targeting of PPARr in diabetic nephropathy.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay
Functional description
PPARr was predicted to be the target of miR-377 and the prediction was verified by luciferase assays. Expression of miR-377 was up-regulated in mesangial cell treated with high glucose (25 mM), and overexpression of miR-377 inhibited PPARr expression and promoted PAI-1 and TGF-b1 expression. The expression of TUG1 antagonized the effect of miR-377 on the downregulation of its target PPARr and inhibited extracellular matrix accumulation, including PAI-1, TGF-b1, fibronectin (FN) and collagen IV (Col IV), induced by high glucose.
Annotations
External Annotation for TUG1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
