Basic Information
Regular Relationship :
Tissue/Cell lineArticular Cartilage Tissues
SpecieHomo sapiens (human)
CitationDNA Cell Biol 2016 Nov 35, 691-695 doi:10.1089/dna.2016.3397 PMID:27529373
Reference title
Long Noncoding RNA UFC1 Promotes Proliferation of Chondrocyte in Osteoarthritis by Acting as a Sponge for miR-34a.
Experimental verification
luciferase reporter assays;qRT-PCR
Functional description
UFC1 was significantly reduced in OA patients. Functional assays demonstrated that UFC1 promotes chondrocytes proliferation and inhibits cell apoptosis. Furthermore, we found that UFC1 regulates survival of OA chondrocytes through physically association with miR-34a.
Annotations
External Annotation for UFC1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
