Detail (Experimental CeRNA)

Home Detail(Experimental CeRNA)

Basic Information

Regular Relationship :


Phenotype/DiseaseSpecie

NA

CeRNA1

BVDV[Viral RNA]

miRNA

miR-7[miRNA]

CeRNA2

NA[mRNA]


Tissue/Cell line

Huh-7,Hek293, Hela And A549

Specie

Bovine viral diarrhea virus 1(BVDV)

Citation

Cell Host Microbe 2016 Mar 9 19, 409-23 doi:10.1016/j.chom.2016.02.007 PMID:26962949


Reference title
A broad RNA virus survey reveals both miRNA dependence and functional sequestration
Experimental verification
luciferase reporter assays

Functional description
For BVDV, around 40% of miR-17 interactions mapped to the virus, suggesting an analogous sponge effect.Along these lines, we reasoned that the BVDV miR-17 sponge effect should result in specific de-repression of cellular miR-17 targets, measurable by mRNA-seq.

Annotations

External Annotation for BVDV
LncRNA-associated competing triplets and functions.
Comprehensive experimentally supported associations between lncRNA and human cancer.
Infer genomic variations that disturb lncRNA-associated ceRNA regulation..
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements.
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data.
Information on all annotated and predicted human genes.
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).
Genome browser for vertebrate genomes.
An annotated collection of all publicly available DNA sequences.
A wiki-based platform for community curation of human long non-coding RNAs.
An integrated knowledge database dedicated to non-coding RNAs.
An integrated database of human annotated lncRNA transcripts.
Comprehensive annotations of eukaryotic long non-coding RNAs.
Comprehensive experimentally supported associations between lncRNA and human cancer.
A comprehensive, authoritative compendium of human genes and genetic phenotypes.
The catalogue of somatic mutations in cancer.

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