Basic Information
Regular Relationship :
Tissue/Cell lineMouse Muscle Tissues
SpecieMus musculus (mouse)
CitationNucleic Acids Res 2014 Dec 16 42, 13799-811 doi:10.1093/nar/gku1160 PMID:25399420
Reference title
The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay
Functional description
Here we report that H19 is significantly decreased in muscle of human subjects with type-2 diabetes and insulin resistant rodents. This decrease leads to increased bioavailability of let-7, causing diminished expression of let-7 targets, which is recapitulated in vitro where H19 depletion results in impaired insulin signaling and decreased glucose uptake. Furthermore, acute hyperinsulinemia downregulates H19, a phenomenon that occurs through PI3K/AKT-dependent phosphorylation of the miRNA processing factor KSRP, which promotes biogenesis of let-7 and its mediated H19 destabilization.
Annotations
External Annotation for H19 |
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An annotated collection of all publicly available DNA sequences. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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