Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieBone Homeostasis Disorder
CeRNA1PDGF[LncRNA]
miRNAmiR-138[miRNA]
CeRNA2Runx2[mRNA]
Tissue/Cell lineMesenchymal Stem Cells
SpecieHomo sapiens (human)
CitationBiochem Biophys Res Commun 2014 Jun 6 448, 241-7 doi:10.1016/j.bbrc.2014.04.091 PMID:24792185
Reference title
PDGF-regulated miRNA-138 inhibits the osteogenic differentiation of mesenchymal stem cells.
Experimental verification
qRT-PCR;Western blot assay
Functional description
We found that PDGF treatment significantly inhibits the osteogenic differentiation of MSCs and that miR-138 gene transcription is controlled by PDGF signaling. Our results confirm that miR-138 inhibits the osteogenic differentiation of MSCs and suppresses the phosphorylation of FAK, ERK1/2, and Runx2. Furthermore, our study clearly demonstrates that downregulation of Runx2 by miR-138 is critical for the PDGF-mediated inhibition of osteogenic differentiation of MSCs.
Annotations
External Annotation for PDGF |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
