Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1CCAT1[LncRNA]
miRNAlet-7c[miRNA]
CeRNA2c-Myc[mRNA]
Tissue/Cell lineSmmc-7721, Hep3B, Huh7, And Hepg2
SpecieMus musculus (mouse)
CitationJ Exp Clin Cancer Res 2015 Feb 19 34, 18 doi:10.1186/s13046-015-0136-7 PMID:25884472
Reference title
Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay
Functional description
CCAT1 functions as a molecular sponge for let-7, antagonizes its functions, and leads to the de-repression of its endogenous targets HMGA2 and c-Myc. The effect of CCAT1 on HCC cell proliferation and migration is dependent upon its competitively binding to let-7. We found that the let-7a, let-7b, let-7c, and let-7e mimics reduced the luciferase activities of the WT reporter vector.
Annotations
External Annotation for CCAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
