Basic Information
Regular Relationship :
Tissue/Cell lineBladder Carcinoma Cells
SpecieHomo sapiens (human)
CitationOncol Res 2018 Aug 23 26, 1063-1072 doi:10.3727/096504018x15152072098476 PMID:29321082
Reference title
Long noncoding RNA ATB promotes proliferation, migration and invasion in bladder cancer by suppressing microRNA-126.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay,in vitro knockdown
Functional description
lncRNA-ATB was a molecular sponge of miR-126, and exerted tumor promoting effects by down-regulation of miR-126. Moreover, KRAS was a direct target of miR-126, and negatively regulated by miR-126. Finally, overexpression of KRAS increased cell viability, migration and invasion, as well as activated PI3K/AKT and mTOR signal pathways in T24 cells.
Annotations
External Annotation for ATB |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
