Basic Information
Regular Relationship :
Tissue/Cell lineNCI-N87, SGC7901, BGC823, BGC803, and AGS
SpecieHomo sapiens (human)
CitationOncol Res 2018 Aug 23 26, 1037-1046 doi:10.3727/096504017x15144748428127 PMID:29295724
Reference title
Long non-coding RNA CAT104 promotes cell viability, migration and invasion in gastric carcinoma cells through activation of microRNA-381 inhibiting zinc finger E-box binding homeobox 1 (ZEB1) expression.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay
Functional description
CAT104 was highly expressed in human GC NCI-N87, SGC7901, BGC823, BGC803 and AGS cells. Suppression of CAT104 decreased NCI-N87 cell viability, migration and invasion, but promoted apoptosis. CAT104 knockdown enhanced the expression of microRNA-381 (miR-381) expression in NCI-N87 cells. miR-381 participated in the regulation effects of CAT104 on NCI-N87 cell viability, migration, invasion and apoptosis. Zinc finger E-box binding homeobox 1 (ZEB1) was identified as a direct target of miR-381. Overexpression of ZEB1 revealed the miR-381 mimicinduced cell viability, migration and invasion inhibition.Suppression of ZEB1 revealed the miR-381 inhibitor-induced activation of c-Jun N-terminal kinase pathway (JNK) and Wnt/ signaling pathways in NCI-N87 cells.
Annotations
External Annotation for CAT104 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
