Basic Information
Regular Relationship :
Tissue/Cell lineMg63 And Os-732,Hfob1.19, Hek293
SpecieHomo sapiens (human)
CitationOncol Res 2018 Dec 27 27, 89-98 doi:10.3727/096504018x15199511344806 PMID:29523223
Reference title
Knockdown of long non-coding RNA CAT104 inhibits the proliferation, migration and invasion of human osteosarcoma cells by regulating microRNA-381.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,in vitro knockdown etc
Functional description
CAT104 was highly expressed in osteosarcoma MG-63 and OS-732 cells. Knockdown of CAT104 significantly inhibited OS-732 cell proliferation, migration and invasion, but promoted cell apoptosis. CAT104 regulated the expression of miR-381 and miR-381 participated in the effects of CAT104 on OS-732 cells. Zinc finger E box binding homeobox 1 (ZEB1) was a direct target gene of miR-381, which was involved in the regulatory roles of miR381 in OS-732 cell proliferation, migration, invasion and apoptosis, as well as c-Jun Nterminal kinase (JNK) and Wnt/-catenin pathways. Suppression of CAT104 exerted significant inhibitory effects on osteosarcoma cell proliferation, migration and invasion by regulating the expression of miR-381 and downstream ZEB1, as well as JNK and Wnt/-catenin pathways.
Annotations
External Annotation for CAT104 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
