Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNon-Small Cell Lung Cancer
CeRNA1DANCR[LncRNA]
miRNAmiR-758-3p[miRNA]
CeRNA2BCL-2[mRNA]
Tissue/Cell lineSpc-A,Ncl-H1650, Ncl-H1975, Sk-Mes-1,A549,Ncl-H358 And Nci-H1299,16Hbe
SpecieHomo sapiens (human)
CitationBiomed Pharmacother 2018 Jul 103, 94-100 doi:10.1016/j.biopha.2018.03.053 PMID:29635134
Reference title
The long non-coding RNA-DANCR exerts oncogenic functions in non-small cell lung cancer via miR-758-3p.
Experimental verification
qPCR,Luciferase reporter assay,in vitro knockdown etc
Functional description
DANCR was markedly upregulated in NSCLC tumor tissues and cell lines compared with related normal controls.The ectopic expression of DANCR significantly increased the proliferation, migration and invasion of SPC-A1 and NCL-H1299 cells. Furthermore, we investigated whether DANCR regulates NSCLC tumor formation in vivo. Subsequently, we concluded that DANCR promotes NSCLC cell proliferation, migration and invasion by regulating the tumor suppressor miR-758-3p.the DANCR/miR-758-3p axis could be a potential target in the treatment of NSCLC.
Annotations
External Annotation for DANCR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
