Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1FABP5P3[LncRNA]
miRNAmiR-589-5p[miRNA]
CeRNA2ZMYND19[mRNA]
Tissue/Cell lineLo2,Hep3B,Hepg2,Huh7, Hcc Tissues
SpecieHomo sapiens (human)
CitationBiochem Biophys Res Commun 2018 Apr 6 498, 551-558 doi:10.1016/j.bbrc.2018.03.017 PMID:29522715
Reference title
LncRNA FABP5P3/miR-589-5p/ZMYND19 axis contributes to hepatocellular carcinoma cell proliferation, migration and invasion.
Experimental verification
qPCR,Luciferase reporter assay,in vitro knockdown etc
Functional description
FABP5P3 that was up-regulated in HCC tissues.Patients with higher FABP5P3 expression displayed poorer survival rate.FABP5P3 depletion in HCC cell lines and sample cells remarkably inhibited the abilities of proliferation, migration and invasion. FABP5P3 bond to miR-589-5p which served as a tumor suppressor. MiR-589-5p targeted directly the mRNA of ZMYND19 whose function has not been defined in HCC.FABP5P3 promoted HCC development and progression by sponging miR-589-5p and up-regulating ZMYND19 expression.FABP5P3/miR-589-5p/ZMYND19 axis regulates cell proliferation and migration in HCC,which may serve as a new target for HCC treatment.
Annotations
External Annotation for FABP5P3 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
