Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieOsteosarcoma
CeRNA1FEZF1-AS1[LncRNA]
miRNAmiR-4443[miRNA]
CeRNA2NUPR1[mRNA]
Tissue/Cell lineU2Os, Saos2, Sw1353, And Mg63, Fetal Osteoblastic Cell Line Hfob
SpecieHomo sapiens (human)
CitationOncol Res 2018 Oct 17 26, 1335-1343 doi:10.3727/096504018x15188367859402 PMID:29510778
Reference title
Long non-coding RNA FEZF1-AS1 promotes osteosarcoma progression by regulating miR-4443/NUPR1 axis.
Experimental verification
RT-PCR,Western blot,Luciferase reporter assay,in vitro knockdown
Functional description
FEZF1-AS1 sponged miR-4443 to promote NUPR1 expression in U2OS and MG63 cells.Furthermore,knockdown of miR-4443 abrogated FEZF1-AS1 silence-induced inhibition of cell proliferation,migration and invasion in osteosarcoma.Finally,we found that restoration of NUPR1 rescued the proliferation,migration and invasion abilities of FEZF1-AS1-depleted U2OS and MG63 cells. In collection,FEZF1-AS1 could promote osteosarcoma progression by sponging miR-4443 to promote NUPR1 expression.The FEZF1-AS1/miR-4443/NUPR1 axis may act as a novel therapeutic strategy for osteosarcoma treatment.
Annotations
External Annotation for FEZF1-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
