Basic Information
Regular Relationship :
Tissue/Cell lineA375,Sk-Mel-1,Sk-Mel-5, Melanoma Tissues
SpecieHomo sapiens (human)
CitationJ Cancer Res Clin Oncol 2018 Mar 144, 531-542 doi:10.1007/s00432-018-2582-z PMID:29350287
Reference title
Long non-coding RNA H19 promotes glucose metabolism and cell growth in malignant melanoma via miR-106a-5p/E2F3 axis.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,in vitro knockdown etc
Functional description
LncRNA H19 was increased in melanoma tissue,and lncRNA H19 was correlated with poor prognosis of melanoma patients.miR-106a-5p acts as a tumour suppressor in melanoma by targeting E2F3.E2F3 affects the melanoma cell glucose metabolism and growth.lncRNA H19 may function as the sponge of miR-106a-5p to up-regulate E2F3 expression,and consequently promote the glucose metabolism and growth of melanoma.
Annotations
External Annotation for H19 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
