Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieOral Squamous Cell Cancer
CeRNA1H19[LncRNA]
miRNAmiR-138[miRNA]
CeRNA2EZH2[mRNA]
Tissue/Cell lineScc-4, Scc-15 , Cal-27, Hsc-3,Hsc-2,Oscc Tissues
SpecieHomo sapiens (human)
CitationInt J Oncol 2018 Mar 52, 901-912 doi:10.3892/ijo.2018.4247 PMID:29344674
Reference title
Long non-coding RNA H1 promotes cell proliferation and invasion by acting as a ceRNA of miR-138 and releasing EZH2 in oral squamous cell carcinoma.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,in vitro knockdown etc
Functional description
The correlation between H19 and microRNA (miR)138 was detected.H19 was found to be upregulated in OSCC tissues and its high expression level was associated with the TNM stage and nodal invasion,and also correlated with a shorter overall survival of patients with OSCC.The knockdown of H19 significantly inhibited OSCC cell proliferation,migration,invasion and epithelial-mesenchymal transition (EMT),and induced apoptosis in vitro.it also suppressed subcutaneous tumor growth in vivo.H19 was found to regulate the expression of oncogene enhancer of zeste homolog 2 (EZH2) by competing with miR138,the inhibition of miR138 attenuated the inhibitory effects of H19 knockdown on OSCC cells.
Annotations
External Annotation for H19 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
