Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieTongue Squamous Cell Carcinoma
CeRNA1H19[LncRNA]
miRNAlet-7a[miRNA]
CeRNA2HMGA2[mRNA]
Tissue/Cell lineCal27, Scc9, Scc15, Scc25,Fadu,Tscc Tissues
SpecieHomo sapiens (human)
CitationOncol Res 2019 Feb 5 27, 173-182 doi:10.3727/096504018x15202945197589 PMID:29523225
Reference title
H19 facilitates tongue squamous cell carcinoma migration and invasion via sponging miR-let-7.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,in vitro knockdown
Functional description
Depletion of H19 impaired the migration and invasion ability of TSCC cells.Mechanisticlly,H19 functions as a competing endogenous RNA (ceRNA) to sponge miRNA let-7a,leading to an increase in a let-7a target, the key regulator of tumor metastasis HMGA2,which is enriched in TSCC tissues and cell lines.Intriguingly,inhibition of let-7a significantly rescued short hairpin H19 (shH19) induced decrease of TSCC migration and invasion.H19/let-7a/HMGA2/EMT axis plays a critical role in the regulation of TSCC migration and invasion,which may provide a new therapeutic target for TSCC cancers.
Annotations
External Annotation for H19 |
|
|---|---|
 |
LncRNA-associated competing triplets and functions. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
 |
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
 |
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
 |
Information on all annotated and predicted human genes. |
 |
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
 |
Genome browser for vertebrate genomes. |
 |
An annotated collection of all publicly available DNA sequences. |
 |
A wiki-based platform for community curation of human long non-coding RNAs. |
 |
An integrated knowledge database dedicated to non-coding RNAs. |
 |
An integrated database of human annotated lncRNA transcripts. |
 |
Comprehensive annotations of eukaryotic long non-coding RNAs. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
 |
The catalogue of somatic mutations in cancer. |
