Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGastric Cancer
CeRNA1HAGLROS[LncRNA]
miRNAmiR-100-5p[miRNA]
CeRNA2ATG9A[mRNA]
Tissue/Cell lineGes1
SpecieHomo sapiens (human)
CitationMol Cancer 2018 Jan 12 17, 6 doi:10.1186/s12943-017-0756-y PMID:29329543
Reference title
STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy.
Experimental verification
RNA-seq,Microarray,qRT-PCR,Western blot,Luciferase reporter assay,in vitro knockdown,RIP
Functional description
HAGLROS,whose expression was significantly increased and correlated with outcomes of GC patients Exogenous down-regulation of HAGLROS expression significantly suppressed the cell proliferation,invasion and migration.HAGLROS was a direct target of transcriptional factor STAT3.Moreover,HAGLROS knockdown decreased mTOR expression and increased autophagy-related genes ATG9A and ATG9B expression.Further,HAGLROS regulated mTOR signals in two manners.HAGLROS competitively sponged miR-100-5p to increase mTOR expression by antagonizing miR-100-5p-mediated mTOR mRNA inhibition.HAGLROS interacted with mTORC1 components to activate mTORC1 signaling pathway which was known to bean important negative signal of autophagy.
Annotations
External Annotation for HAGLROS |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
