Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieFollicular Thyroid Cancer
CeRNA1HCP5[LncRNA]
miRNAmiR-22-3p[miRNA]
CeRNA2ST6GAL2[mRNA]
Tissue/Cell lineFtc-133,Ftc-238,Nthy-Ori 3-1,Hek293T,Huvecs ,Ftc Tissues
SpecieHomo sapiens (human)
CitationCell Death Dis 2018 Mar 7 9, 372 doi:10.1038/s41419-018-0382-7 PMID:29515098
Reference title
LncRNA HCP5 promotes follicular thyroid carcinoma progression via miRNAs sponge.
Experimental verification
RNA-seq,qPCR,RNAi etc
Functional description
Overexpression of HCP5 can promote the proliferation,migration,invasiveness and angiogenic ability of FTC cells.HCP5 and alpha-2,6-sialyltransferase 2 (ST6GAL2) were co-expressed in FTC.We hypothesised that ST6GAL2 may be regulated by HCP5, which would in turn mediate the activity of FTC cells.HCP5 functions as a competing endogenous RNA (ceRNA) and acts as a sponge for miR-22-3p, miR-186-5p and miR-216a-5p, which activates ST6GAL2.
Annotations
External Annotation for HCP5 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
