Basic Information
Regular Relationship :
Tissue/Cell lineU-87 Mg
SpecieHomo sapiens (human)
CitationJ Cell Biochem 2018 Jun 119, 4540-4547 doi:10.1002/jcb.26591 PMID:29323737
Reference title
MiR-15b/HOTAIR/p53 form a regulatory loop that affects the growth of glioma cells.
Experimental verification
qPCR,Western blot etc
Functional description
The present study further demonstrated that miR-15b, HOTAIR, and p53 formed a mutually regulated loop.MiR-15b upregulated the expression of p53 but inhibited the expression of HOTAIR.In addition,miR-15b was able to regulate the expression of HOTAIR through p53.P53 promoted miR-15b expression but inhibited HOTAIR expression.Furthermore,the examination of cell proliferation,apoptosis,and invasion revealed that both miR-15b and p53 inhibited the proliferation and invasion,but promoted the apoptosis,of glioma cells.In contrast,HOTAIR exerted effects that were the opposite of those exerted by miR-15b and p53 on glioma cells.The upregulation of HOTAIR suppressed the inhibitory effects of miR-15b and p53 on cell proliferation and invasion as well as the promoting effect of miR-15b and p53 on apoptosis.Therefore,it can be concluded that miR-15b,HOTAIR,and p53 constitute a regulatory loop that is capable of regulating the growth of glioma cells.
Annotations
External Annotation for HOTAIR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
