Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCervical Cancer
CeRNA1HOTAIR[LncRNA]
miRNAmiR-133a-3p[miRNA]
CeRNA2XIRP1[mRNA]
Tissue/Cell lineCervical Cancer tissues
SpecieHomo sapiens (human)
CitationMol Med Rep 2018 Jun 17, 7845-7858 doi:10.3892/mmr.2018.8846 PMID:29620291
Reference title
Integrated analysis of long non-coding RNA competing interactions revealed potential biomarkers in cervical cancer: Based on a public database.
Experimental verification
qPCR etc
Functional description
HOTAIR and UCA1 both were significantly higher expressed in GC tumor tissues than adjacent non-tumor tissues.The results from the qRT-PCR validation in 82 newly diagnosed GC patients and the above bioinformatics results were 100% in agreement. To further analyze the association between the 2 key lncRNAs and clinicopathological characteristics of 82 GC patients, we found that HOTAIR was significantly associated with tumor size and lymphatic metastasis, and UCA1 was significantly associated with tumor size,TNM stage and lymphatic metastasis. HOTAIR and UCA1 were found to be significantly associated with overall survival.The miR-1 was downexpressed when lncRNA UCA1 was overexpressed in glioma cells.mRNA XIRP1 was found to interact with miRNA miR-133a-3p. Key miRNA miR-133a-3p was predicted to target key lncRNA HOTAIR.
Annotations
External Annotation for HOTAIR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
