Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCervical Cancer
CeRNA1HOTAIR[LncRNA]
miRNAmiR-143-3p[miRNA]
CeRNA2BCL2[mRNA]
Tissue/Cell lineSiha, Hela, Caski, C4-1 And Hacat
SpecieHomo sapiens (human)
CitationCancer Biol Ther 2018 May 4 19, 391-399 doi:10.1080/15384047.2018.1423921 PMID:29336659
Reference title
Long non-coding RNA HOTAIR promotes cervical cancer progression through regulating BCL2 via targeting miR-143-3p.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,RIP etc
Functional description
HOTAIR expression was elevated while miR-143-3p expression was reduced in cervical cancer tissues and cell lines.HOTAIR knockdown suppressed proliferation and enhanced apoptosis in cervical cancer cells.Moreover, HOTAIR could function as a sponge for miR-143-3p.The inhibitory effect of HOTAIR knockdown on cervical cancer cells growth was abolished following decrease of miR-143-3p expression.Furthermore, HOTAIR promoted BCL2 expression by modulating miR-143-3p.BCL2 overexpression attenuated the tumor-suppressive effect of miR-143-3p in cervical cancer.Finally, the carcinogenicity of HOTAIR was validated in mice.HOTAIR acted as a ceRNA to modulate BCL2 expression via competitively binding to miR-143-3p.
Annotations
External Annotation for HOTAIR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
