Basic Information
Regular Relationship :
Tissue/Cell lineNbt, Glioma Cell Lines
SpecieHomo sapiens (human)
CitationJ Cell Physiol 2018 Sep 233, 6822-6831 doi:10.1002/jcp.26432 PMID:29319172
Reference title
Long non-coding RNA HOTAIR acts as a competing endogenous RNA to promote glioma progression by sponging miR-126-5p.
Experimental verification
Microarray,qRT-PCR,Western blot,Luciferase reporter assay
Functional description
HOTAIR was aberrantly up-regulated in glioma tissues and was negatively correlated with miR-126-5p expression.Next, we determined that HOTAIR promote glioma progression by sponging miR-126-5p.Subsequently,glutaminase (GLS) was confirmed to be a direct target of miR-126-5p.Moreover,HOTAIR could modulate GLS expression by functioning as a competing endogenous RNA (ceRNA) for miR-126-5p.
Annotations
External Annotation for HOTAIR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
