Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieBreast Cancer
CeRNA1HOTAIR[LncRNA]
miRNAmiR-20a-5p[miRNA]
CeRNA2HMGA2[mRNA]
Tissue/Cell lineMcf7, Skbr3, Mda-Mb- 231 ,Mcf- 10A,Bc Tissues
SpecieHomo sapiens (human)
CitationCancer Med 2018 Mar 7, 842-855 doi:10.1002/cam4.1353 PMID:29473328
Reference title
LncRNA HOTAIR influences cell growth, migration, invasion, and apoptosis via the miR-20a-5p/HMGA2 axis in breast cancer.
Experimental verification
qPCR,Western blot,in vitro knockdown
Functional description
The expression levels of the lncRNA HOTAIR were upregulated in BC tissues and cells.Knockdown lncRNA HOTAIR inhibited cell propagation and metastasis and facilitated cell apoptosis.MiR-20a-5p was a target of lncRNA HOTAIR and had a negative correlation with lncRNA HOTAIR.MiR-20a-5p overexpression in BC suppressed cell growth,mobility,and invasiveness and facilitated apoptosis.HMGA2 was a target of miR-20a-5p,which significantly induced carcinogenesis of BC.BC cells progression was mediated by lncRNA HOTAIR via affecting miR-20a-5p/HMGA2 in vivo.LncRNA HOTAIR affected cell growth, metastasis,and apoptosis via the miR-20a-5p/HMGA2 axis in breast cancer.
Annotations
External Annotation for HOTAIR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
