Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieSmall Cell Lung Cancer
CeRNA1HOTTIP[LncRNA]
miRNAmiR-216a[miRNA]
CeRNA2BCL-2[mRNA]
Tissue/Cell lineH69, H69Ar, H446, H446Ar And Alveolar Epithelial Cell Line
SpecieHomo sapiens (human)
CitationCell Death Dis 2018 Jan 24 9, 85 doi:10.1038/s41419-017-0113-5 PMID:29367594
Reference title
Long non-coding RNA HOTTIP promotes BCL-2 expression and induces chemoresistance in small cell lung cancer by sponging miR-216a.
Experimental verification
Microarray,RT-qPCR,Western blot,Luciferase reporter assay,in vitro knockdown,RNAi,RIP
Functional description
HOTTIP functioned as an oncogene in SCLC progression by binding miR-216a and abrogating its tumor-suppressive function in this setting.On the other hand,HOTTIP increased the expression of anti-apoptotic factor BCL-2,another important target gene of miR-216a,and jointly enhanced chemoresistance of SCLC by regulating BCL-2.
Annotations
External Annotation for HOTTIP |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
