Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1HOXA11-AS[LncRNA]
miRNAmiR-214-3p[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineHep3B, Smmc-7721, Mhcc97-H, Bel-7402 And Hl-7702
SpecieHomo sapiens (human)
CitationJ Cell Mol Med 2018 May 15 22, 3758-67 doi:10.1111/jcmm.13633 PMID:29761918
Reference title
LncRNA HOXA11-AS promotes hepatocellular carcinoma progression by repressing miR-214-3p.
Experimental verification
qPCR,Western blot etc
Functional description
HOXA11-AS expression was up-regulated in the HCC tissues,and the higher expression of HOXA11-AS was associated with the advanced stage in the HCC samples.In addition,the expression of HOXA11-AS was up-regulated in HCC cell lines compared with normal liver cell lines. Overexpression of HOXA11-AS promoted HCC proliferation and invasion and induced the epithelial-mesenchymal transition (EMT) and knockdown of HOXA11-AS suppressed the HCC cell proliferation and invasion .However, we showed that miR-214-3p expression was down-regulated in the HCC tissues and cell lines.Ectopic expression of miR-214-3p suppressed HCC cell proliferation and invasion.Furthermore,we indicated that overexpression of HOXA11-AS decreased the miR-214-3p expression and the expression of miR-214-3p was negatively related with the HOXA11-AS expression in HCC samples. Ectopic expression of HOXA11-AS increased HCC proliferation and invasion and induced EMT through inhibiting miR-214-3p expression.These data suggested that HOXA11-AS/miR-214-3p axis was responsible for development of HCC. We ndemonstrated that miR-214-3p expression was down-regulated in the HCC tissues and the expression of miR-214-3p was negatively correlated with the expression of HOXA11-AS.
Annotations
External Annotation for HOXA11-AS |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
