Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieLung Cancer
CeRNA1HOXA11-AS[LncRNA]
miRNAmiR-642b-3p[miRNA]
CeRNA2PDE4D[mRNA]
Tissue/Cell lineA549
SpecieHomo sapiens (human)
CitationOncol Lett 2018 May 15, 6147-6160 doi:10.3892/ol.2018.8105 PMID:29616096
Reference title
A comprehensive analysis of the predicted targets of miR-642b-3p associated with the long non-coding RNA HOXA11-AS in NSCLC cells.
Experimental verification
qPCR etc
Functional description
The transfection efficiency was ~100%,and the knockdown efficiency of HOXA11 AS in NSCLC cell lines was >75%, as determined by a reverse transcription quantitative polymerase chain reaction.Following the knockdown of HOXA11-AS,miR-642b-3p was significantly downregulated in A549 NSCLC cells.The ROC curve revealed that the area under curve (AUC) of HOXA11-AS was 0.700 for patients with lung adenocarcinoma and 0.964 for patients with squamous cell carcinoma,which may gain a moderate or high diagnostic value of HOXA11-AS level in lung cancer.
Annotations
External Annotation for HOXA11-AS |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
