Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGlioblastoma
CeRNA1HOXD-AS1[LncRNA]
miRNAmiR-130a[miRNA]
CeRNA2E2F8[mRNA]
Tissue/Cell lineHek-293T
SpecieHomo sapiens (human)
CitationInt J Cancer 2018 Jun 1 142, 2313-2322 doi:10.1002/ijc.31262 PMID:29341117
Reference title
HOXD-AS1/miR-130a sponge regulates glioma development by targeting E2F8.
Experimental verification
qPCR,Western blot,Luciferase reporter assay etc
Functional description
HOXD-AS1 expression was upregulated in glioma tissues and in glioma cell lines.HOXD-AS1 overexpression promoted cell migration and invasion in vitro, whereas knockdown of HOXD-AS1 expression repressed these cellular processes. Mechanistic studies further revealed that HOXD-AS1 could compete with the transcription factor E2F8 to bind with miR-130a,thus affecting E2F8 expression. Additionally, reciprocal repression was observed between HOXD-AS1 and miR-130a,and miR-130a mediated the tumor-suppressive effects of HOXD-AS1 knockdown.
Annotations
External Annotation for HOXD-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
