Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieProstate Cancer
CeRNA1HULC[LncRNA]
miRNAmiR-200a-3p[miRNA]
CeRNA2ZEB1[mRNA]
Tissue/Cell lineLncap, Pc3,Du145,Rwpe-1,Pca Tissues
SpecieHomo sapiens (human)
CitationArch Med Sci 2018 Apr 14, 679-686 doi:10.5114/aoms.2017.69147 PMID:29765457
Reference title
High lncRNA HULC expression is associated with poor prognosis and promotes tumor progression by regulating epithelial-mesenchymal transition in prostate cancer.
Experimental verification
qPCR,Western blot,Luciferase reporter assay etc
Functional description
HULC expression was upregulated in PCa tissues and cell lines compared to adjacent non-tumor tissues and the normal prostate cell line RWPE-1. High HULC expression was positively associated with advanced clinicopathologic features and poor overall survival (OS) for PCa patients.HULC inhibition suppressed PCa cell growth and metastasis both in vitro and in vivo.Furthermore, HULC knockdown reduced N-cadherin and vimentin expression and increased E-cadherin expression in PCa cells.LncRNA HULC might play oncogenic roles in PCa progression, which provided a novel therapeutic strategy for PCa patients.lncRNA HULC enhanced epithelial mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1.
Annotations
External Annotation for HULC |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
