Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1KCNQ1OT1[LncRNA]
miRNAmiR-504[miRNA]
CeRNA2CDK16[mRNA]
Tissue/Cell lineHuh-7, Smmc-7721,Hep3B, Mhcc97-H And Mhcc97-L,Lo2,293T,Hcc Tissues
SpecieHomo sapiens (human)
CitationInt J Oncol 2018 May 52, 1603-1612 doi:10.3892/ijo.2018.4313 PMID:29532864
Reference title
Long non-coding RNA KCNQ1OT1 mediates the growth of hepatocellular carcinoma by functioning as a competing endogenous RNA of miR-504.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,in vitro knockdown etc
Functional description
The ectopic high expression of KCNQ1OT1 was associated with liver cirrhosis,a larger tumor size, an advanced TNM stage,and a worse overall survival and tumorfree survival.KCNQ1OT1 exerted its effects partly by relying on the microRNA504 (miR504)mediated regulation of cyclindependent kinase 16 (CDK16),in addition to the regulation of the glycogen synthase kinase 3β (GSK3β)/βcatenin/Bcl2 signaling pathway. The present study revealed the functions and mechanisms of action of lncRNA KCNQ1OT1 regarding its role in promoting the growth of HCC.KCNQ1OT1 may prove to be a potential therapeutic target for human HCC.
Annotations
External Annotation for KCNQ1OT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
