Basic Information
Regular Relationship :
Tissue/Cell lineHacat, A375, A875 And Mum-2C
SpecieHomo sapiens (human)
CitationAging (Albany NY) 2018 Apr 17 10, 632-644 doi:10.18632/aging.101418 PMID:29667930
Reference title
KCNQ1OT1 promotes melanoma growth and metastasis.
Experimental verification
Microarray,qPCR,Western blot etc
Functional description
KCNQ1OT1 expression is up-regulated in melanoma tissues and cells.KCNQ1OT1 promoted cell proliferation and metastasis in melanoma.By directly bindin to miR-153,KCNQ1OT1 acted as a competing endogenous RNA (ceRNA) to de-repress MET expression.
Annotations
External Annotation for KCNQ1OT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
