Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGastric Cancer
CeRNA1LINC00152[LncRNA]
miRNAmiR-193a-3p[miRNA]
CeRNA2MCL1[mRNA]
Tissue/Cell lineMgc-803, Ags, Sgc-7901, Bgc-823 And Ges-1
SpecieHomo sapiens (human)
CitationBiosci Rep 2018 Jun 29 38 doi:10.1042/bsr20171607 PMID:29339419
Reference title
LINC00152 down-regulated miR-193a-3p to enhance MCL1 expression and promote gastric cancer cells proliferation.
Experimental verification
Microarray,qPCR,Western blot,RNAi etc
Functional description
LINC00152 was proven to have a higher expression level in GC tissues than in the adjacent normal tissues.GC cells proliferation was inhibited after LINC00152 was down-regulated.LINC00152 inhibited the expression of miR-193a-3p,which negatively regulated MCL1 In addition,GC cells proliferation was inhibited by cell transfection with shRNA-MCL1,and enhanced by transfection with miR-193a-3p mimics. Our study suggested that LINC00152 was overexpressed in GC tissues,and it down-regulated miR-193a-3p to enhance miR-193a-3p expression thereby promoting GC cells proliferation.Furthermore,an interesting discovery is that LINC00152 works as a competing endogenous RNA (ceRNA) through sponging miR-193a-3p and shares the identical responsive elements of miR-193a-3p with some signaling pathway factor like erb-b2 receptor tyrosine kinase 4 (ERBB4).
Annotations
External Annotation for LINC00152 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
