Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieLung Cancer
CeRNA1LINC00319[LncRNA]
miRNAmiR-450b-5p[miRNA]
CeRNA2EZH2[mRNA]
Tissue/Cell lineH157, 95D, Spc-A-1, A549, Sk-Lu-1, Calu-3, Hcc-78, H1299 And H1975
SpecieHomo sapiens (human)
CitationGene 2018 Apr 15 650, 60-67 doi:10.1016/j.gene.2018.01.096 PMID:29408583
Reference title
Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2.
Experimental verification
qPCR,Luciferase reporter assay etc
Functional description
We observed that increased expression of LINC00319 in lung adenocarcinoma tissues and cells in comparison to their corresponding controls.Moreover,the aberrant overexpression of LINC00319 indicated the poor prognosis of lung adenocarcinoma patients.Silence of LINC00319 was able to repress lung adenocarcinoma cell growth in vitro.Rescue assay was performed to further confirm that LINC00319 contributed to lung adenocarcinoma progression by regulating miR-450b-5p/EZH2 signal pathway.Taken together, our study discovered the oncogenic role of LINC00319 in clinical specimens and cellular experiments,showing the potential LINC00319/miR-450b-5p/EZH2 pathway.This results and findings provide a novel insight for lung adenocarcinoma tumorigenesis.
Annotations
External Annotation for LINC00319 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
