Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGastric Cancer
CeRNA1LINC00483[LncRNA]
miRNAmiR-30a-3p[miRNA]
CeRNA2SPAG9[mRNA]
Tissue/Cell lineSgc7901, Bgc823, Mgc803, Mnk28 And Ges-1
SpecieHomo sapiens (human)
CitationJ Cell Mol Med 2018 May 15 22, 3875-86 doi:10.1111/jcmm.13661 PMID:29761936
Reference title
Linc00483 as ceRNA regulates proliferation and apoptosis through activating MAPKs in gastric cancer.
Experimental verification
qPCR,Western blot etc
Functional description
linc00483 promoted gastric cancer cell proliferation,invasiveness and metastasis in vitro and in vivo.Mechanistically, upregulated expression of linc00483 in gastric cancer acts as a sponge to absorb endogenous tumour suppressor miR-30a-3p. Furthermore,it restores SPAG9 expression, which is negatively regulated by miR-30a-3p,and actives MAPK signaling pathway in gastric cancer cells.Thus,linc00483 is an oncogenic lncRNA in gastric cancer and targeting linc00483 or its pathway can potentially be useful in development of targeted therapies for patients with gastric cancer.linc00483 is an important regulator in carcinogenesis and may be a useful biomarker to predict prognosis of gastric cancer patients.Linc00483 regulates SPAG9 by acting as a ceRNA and interacting with miR-30a-3p.
Annotations
External Annotation for LINC00483 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
