Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieTongue Squamous Cell Carcinoma
CeRNA1LINC00511[LncRNA]
miRNAmiR-765[miRNA]
CeRNA2LAMC2[mRNA]
Tissue/Cell lineHoec, Tca-8113, Scc-9, Scc-4 And Cal-2
SpecieHomo sapiens (human)
CitationJ Oral Pathol Med 2018 May 47, 468-476 doi:10.1111/jop.12677 PMID:29315846
Reference title
LINC00511 interacts with miR-765 and modulates tongue squamous cell carcinoma progression by targeting LAMC2.
Experimental verification
Microarray,qPCR,Western blot,Luciferase reporter assay etc
Functional description
LINC00511 was obviously upregulated in TSCC tissues and cell lines.Moreover,it was found that LINC00511 served as a competing endogenous RNA (ceRNA) through sponging miR-765 and ultimately modulated the derepression of laminin subunit gamma 2 (LAMC2).The inhibitory effects of miR-765 on TSCC cells proliferation,invasion as well as cell cycle distribution can be restored by the ectopic overexpression of LINC00511. Additionally, the restored capacity of LINC00511 promoted the expression of LAMC2, which was a downstream target of miR-765 and can be negatively regulated by miR-765. A novel molecular axis of LINC00511/miR-765/LAMC2 was investigated to regulate the tumor development of TSCC. LINC00511 promoted the expression of LAMC2 via the ceRNA mechanism of sponging miR-765.
Annotations
External Annotation for LINC00511 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
