Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieEndometrial Cancer
CeRNA1LINC01016[LncRNA]
miRNAmiR-302a-3p[miRNA]
CeRNA2SATB1[mRNA]
Tissue/Cell lineIshikawa And Rl-95-, Embryonic Kidney Cell Line
SpecieHomo sapiens (human)
CitationCell Death Dis 2018 Feb 21 9, 303 doi:10.1038/s41419-018-0291-9 PMID:29467441
Reference title
LINC01016 promotes the malignant phenotype of endometrial cancer cells by regulating the miR-302a-3p/miR-3130-3p/NFYA/SATB1 axis.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay,in vitro knockdown
Functional description
LINC01016 was substantially upregulated in endometrial cancer tissues,and LINC01016 silencing abolished the malignant behavior of endometrial cancer cells.LINC01016 positively rescued the downstream gene nuclear factor YA (NFYA) by competitively "sponging" miR-302a-3p and miR-3130-3p.In turn, these two miRNAs could inhibit LINC01016 transcription,thus forming two reciprocal repression cycles,which influenced the biological behavior of endometrial cancer cells.MiR-302a-3p and miR-3130-3p could specifically bind with the 3'-UTR regions of NFYA, and NFYA could upregulate the expression of special AT-rich sequence-binding protein 1 (SATB1) as a transcriptional factor.This study was the first to show that the LINC01016-miR-302a-3p/miR-3130-3p/NFYA/SATB1 axis played a crucial role in the occurrence of endometrial cancer.
Annotations
External Annotation for LINC01016 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
