Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGastric Cancer
CeRNA1LINC01234[LncRNA]
miRNAmiR-204-5p[miRNA]
CeRNA2CBFB[mRNA]
Tissue/Cell lineGes-1, Bgc823, Sgc7901, Ags, Hgc27, Mgc803
SpecieHomo sapiens (human)
CitationClin Cancer Res 2018 Apr 15 24, 2002-2014 doi:10.1158/1078-0432.Ccr-17-2376 PMID:29386218
Reference title
Long Noncoding RNA LINC01234 Functions as a Competing Endogenous RNA to Regulate CBFB Expression by Sponging miR-204-5p in Gastric Cancer.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,RIP etc
Functional description
LINC01234 expression was significantly upregulated in gastric cancer tissues and was associated with larger tumor size, advanced TNM stage,lymph node metastasis,and shorter survival time.Furthermore,knockdown of LINC01234-induced apoptosis and growth arrest in vitro and inhibited tumorigenesis in mouse xenografts.Mechanistic investigations indicated that LINC01234 functioned as a ceRNA for miR-204-5p,thereby leading to the derepression of its endogenous target core-binding factor β (CBFB).LINC01234 is significantly overexpressed in gastric cancer, and LINC01234-miR-204-5p-CBFB axis plays a critical role in gastric cancer tumorigenesis.
Annotations
External Annotation for LINC01234 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
