Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColon Cancer
CeRNA1LINC01296[LncRNA]
miRNAmiR-21a[miRNA]
CeRNA2PTEN[mRNA]
Tissue/Cell lineCcd841A, Sw480, Dld-1, Hct116, Sw620, Caco-2 And Ht29
SpecieHomo sapiens (human)
CitationOncol Res 2019 May 7 27, 541-549 doi:10.3727/096504018x15234931503876 PMID:29673421
Reference title
Long noncoding RNA LINC01296 harbors miR-21a to regulate colon carcinoma proliferation and invasion.
Experimental verification
qPCR,RIP etc
Functional description
LINC01296 was upregulated in CC cancerous tissues and cell lines compared to adjacent normal tissue and normal liver cell lines. Besides, LINC01296 overexpression was associated with poor prognostic and lower survival rate.Moreover, LINC01296 silencing inhibited the proliferation, invasion of CC cells in vitro detected by epithelialmesenchymal transition (EMT). Bioinformatics analysis revealed that miR-21a targeted 3'-UTR of LINC01296. Rescue experiments confirmed that miR-21a could reverse the function of LINC01296 on CC cells.The expression of LINC01296 and mir-21a is negatively correlated in CC.
Annotations
External Annotation for LINC01296 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
