Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNA
CeRNA1mir-15 sponge[Artifically engineered RNA]
miRNAmiR-15a[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineHek293T
SpecieHomo sapiens (human)
CitationNat Methods 2007 Sep 4, 721-6 doi:10.1038/nmeth1079 PMID:17694064
Reference title
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays
Functional description
We made decoy targets for several microRNA seed families, named them ‘microRNA sponges’, and tested their ability to derepress microRNA targets in mammalian cells.
Annotations
External Annotation for mir-15 sponge |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
