Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieEsophageal Squamous Cancer
CeRNA1LUCAT1[LncRNA]
miRNAmiR-375[miRNA]
CeRNA2DNMT1[mRNA]
Tissue/Cell lineKyse-30,Te-2, Hce-4,Hce-7, Escc Tissues
SpecieHomo sapiens (human)
CitationCancer Lett 2018 Mar 28 417, 47-57 doi:10.1016/j.canlet.2017.12.016 PMID:29247823
Reference title
The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma.
Experimental verification
qPCR,Western blot,RIP,in vitro knockdown etc
Functional description
LUCAT1 knockdown reduced cell proliferation,induced apoptosis, and upregulated tumor-suppressor genes by reducing DNA methylation in KYSE-30cells. Moreover, LUCAT1 siRNA reduced DNA methyltransferase 1 (DNMT1) protein levels without affecting transcription. LUCAT1 regulates the stability of DNMT1 and inhibits the expression of tumor suppressors through DNA methylation,leading to the formation and metastasis of ESCC.
Annotations
External Annotation for LUCAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
