Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieProstate Cancer
CeRNA1MALAT1[LncRNA]
miRNAmiR-145-5p[miRNA]
CeRNA2AKAP12[mRNA]
Tissue/Cell lineDu145 And Pc3,Hek-293T ,Pca Tissues
SpecieHomo sapiens (human)
CitationJ Cell Mol Med 2018 Jun 22, 3223-3237 doi:10.1111/jcmm.13604 PMID:29633510
Reference title
Long noncoding RNA MALAT1 enhances the docetaxel resistance of prostate cancer cells via miR-145-5p-mediated regulation of AKAP12.
Experimental verification
qPCR,Western blot,Luciferase reporter assay etc
Functional description
MALAT1 expression levels were up-regulated in clinical DTX-resistant PCa samples.Overexpressed MALAT1 promoted cell proliferation,migration and invasion but decreased cell apoptosis rate of PCa cells in spite of DTX treatment.We identified miR-145-5p as a target of MALAT1.MiR-145-5p overexpression in PC3-DTX led to inhibited cell proliferation, migration and invasion as well as reduced chemoresistance to DTX,which was attenuated by MALAT1.Moreover,we determined that AKAP12 was a target of miR-145-5p,which significantly induced chemoresistance of PCa cells to DTX. Besides,it was proved that MALAT1 promoted tumour cell proliferation and enhanced DTX-chemoresistance in vivo.There was an lncRNA MALAT1/miR-145-5p/AKAP12 axis involved in DTX resistance of PCa cells and provided a new thought for PCa therapy.
Annotations
External Annotation for MALAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
