Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieRetinoblastoma
CeRNA1MALAT1[LncRNA]
miRNAmiR-124[miRNA]
CeRNA2SNARE[mRNA]
Tissue/Cell lineY79, Weri-Rb1, So-Rb50 And Hxo-Rb44
SpecieHomo sapiens (human)
CitationJ Cell Biochem 2018 May 119, 3853-3863 doi:10.1002/jcb.26464 PMID:29073720
Reference title
MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation.
Experimental verification
qPCR,Western blot,Luciferase reporter assay etc
Functional description
Through direct targeting miR-124,MALAT1 promotes retinoblastoma cell autophagy. Further,we investigated whether Syntaxin 17 (STX17),a Soluble NSF Attachment Protein receptor (SNARE) of the autophagosome, is involved in MALAT1/miR-124 regulation of retinoblastoma cell autophagy, and the underlying mechanism.
Annotations
External Annotation for MALAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
