Basic Information
Regular Relationship :
Tissue/Cell lineMg63 And U2Os
SpecieHomo sapiens (human)
CitationOncol Res 2018 Apr 27, 10.3727/096504017x14957939026111 doi:10.3727/096504017x14957939026111 PMID:28560950
Reference title
MALAT1 Promotes the Proliferation and Metastasis of Osteosarcoma Cells By Activating the Rac1/JNK Pathway Via Targeting MiR-509.
Experimental verification
qPCR,Western blot,Luciferase reporter assay etc
Functional description
MALAT1 was increased in human OS tissues and cell lines.MALAT1 knockdown suppressed OS cell growth and metastasis,induced OS cell apoptosis and delayed tumor growth in an OS xenograft model.We also detected downregulation of microRNA-509 (miR-509), a suppressor of OS growth,in OS tissues and cell lines.Then,we identified that miR-509 is a direct target of MALAT1 and Ras-related C3 botulinum toxin substrate 1 (Rac1) is a direct target of miR-509.MALAT1 may promote OS cell growth through inhibition of miR-509, leading to the activation of Rac1/JNK pathway.Our results suggest a MALAT1/miR-509/Rac1 axis that mediates OS cell proliferation and tumor progression.
Annotations
External Annotation for MALAT1 |
|
|---|---|
 |
LncRNA-associated competing triplets and functions. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
 |
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
 |
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
 |
Information on all annotated and predicted human genes. |
 |
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
 |
Genome browser for vertebrate genomes. |
 |
An annotated collection of all publicly available DNA sequences. |
 |
A wiki-based platform for community curation of human long non-coding RNAs. |
 |
An integrated knowledge database dedicated to non-coding RNAs. |
 |
An integrated database of human annotated lncRNA transcripts. |
 |
Comprehensive annotations of eukaryotic long non-coding RNAs. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
 |
The catalogue of somatic mutations in cancer. |
