Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGastric Cancer
CeRNA1MAP3K20[LncRNA]
miRNAmiR-375[miRNA]
CeRNA2JAK2[mRNA]
Tissue/Cell lineHgc27, Sgc7901, Mgc803, Ags And Mkn-45,Ges-1,Gastric Cancer Tissues
SpecieHomo sapiens (human)
CitationBiochem Biophys Res Commun 2018 Mar 4 497, 527-534 doi:10.1016/j.bbrc.2018.02.072 PMID:29428732
Reference title
Knockdown of long non-coding RNA MAP3K20 antisense RNA 1 inhibits gastric cancer growth through epigenetically regulating miR-375.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,in vitro knockdown, RIP etc
Functional description
MLK7-AS1 interacted with Dnmt1 and recruited it to miR-375 promotor, hyper-methylating miR-375 promotor and repressing miR-375 expression. Our findings demonstrate that knockdown of MLK7-AS1 by siRNA inhibits gastric cancer growth by epigenetically regulating miR-375. Knockdown of MLK7-AS1 by siRNA increased the expression of miR-375. MiR-375 wasfound to be an important tumor suppressor in gastric cancer bytargeting Janus kinase 2 (JAK2).
Annotations
External Annotation for MAP3K20 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
