Basic Information
Regular Relationship :
Tissue/Cell lineBgc-823,Mgc-803,Gastric Cancer Tissues
SpecieHomo sapiens (human)
CitationJ Exp Clin Cancer Res 2018 Mar 14 37, 58 doi:10.1186/s13046-018-0725-3 PMID:29540201
Reference title
Long non-coding RNA MIAT promotes gastric cancer growth and metastasis through regulation of miR-141/DDX5 pathway.
Experimental verification
qPCR,RIP,Western blot,Luciferase reporter assay,in vitro knockdown etc
Functional description
MIAT was highly expressed in GC tissues and cell lines and correlated with differentiation degree, TNM stage, distant metastasis, and lymph node metastasis.MIAT knockdown inhibited GC growth and metastasis both in vitro and in vivo. MIAT acted as miR-141 sponge and regulated its target gene DDX5 expression.In BGC-823 and MGC-803 cells with si-MIAT,DDX5 overexpression resulted in an increase of cell proliferation, migration and invasion. Our data indicated that MIAT played an oncogenic role in GC growth and metastasis,and could serve as a novel molecular target for treating GC.
Annotations
External Annotation for MIAT |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
