Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1MIAT[LncRNA]
miRNAmiR-132[miRNA]
CeRNA2Derlin-1[mRNA]
Tissue/Cell lineHcoepic, Ht-29, Sw480, And Lovo
SpecieHomo sapiens (human)
CitationCancer Cell Int 2018 18, 59 doi:10.1186/s12935-017-0477-8 PMID:29686537
Reference title
Long non-coding RNA MIAT promotes growth and metastasis of colorectal cancer cells through regulation of miR-132/Derlin-1 pathway.
Experimental verification
qPCR,Western blot,Luciferase reporter assay etc
Functional description
MIAT was highly expressed in CRC tissues and cells.MIAT knockdown inhibited proliferation,migration and invasion and enhanced apoptosis of CRC cells.Further,we demonstrated that MIAT acted as a competing endogenous RNA for miR-132, antagonized its functions,and resulted in the de-repression of its target gene Derlin-1,which acted as an oncogene in promoting growth and metastasis of CRC cells.In LOVO and SW480 cells with si-MIAT, miR-132 inhibitor resulted in an increase of cell proliferation, migration and invasion and a decrease of cell apoptosis, which was partially abolished by transfection of Derlin-1 shRNA.Our data indicated that highly expressed MIAT was an oncogenic lncRNA that promoted the growth and metastasis of CRC through miR-132/Derlin-1 axis.
Annotations
External Annotation for MIAT |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
