Basic Information
Regular Relationship :
Tissue/Cell lineU138, Ln229, T98 And U251
SpecieHomo sapiens (human)
CitationOncol Res 2019 Feb 21 27, 341-347 doi:10.3727/096504018x15228909735079 PMID:29678219
Reference title
LncRNA MNX1-AS1 promotes glioblastoma progression through inhibition of miR-4443.
Experimental verification
qPCR etc
Functional description
the expression of MNX1-AS1 was significantly upregulated in GBM tissues and cell lines. Knockdown of MNX1-AS1 significantly inhibited the proliferation,migration and invasion of GBM cells. In terms of mechanism,we found that MNX1-AS1 could bind to miR-4443 in GBM cells. Overexpression of miR-4443 significantly inhibited the expression of MNX1-AS1, and vice versa. Moreover,there was an inverse correlation between the expression levels of MNX1-AS1 and miR-4443 in GBM tissues. Moreover,we found that overexpression of miR-4443 inhibited the proliferation, migration and invasion of GBM cells. Besides,we showed that inhibition of miR-4443 reversed the effects of MNX1-AS1 knockdown on GBM cell proliferation, migration and invasion. Taken together, we found that MNX1-AS1 promoted the proliferation,migration and invasion of GBM cells through inhibiting miR-4443.
Annotations
External Annotation for MNX1-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
