Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieOral Squamous Cell Cancer
CeRNA1NEAT1[LncRNA]
miRNAmiR-365[miRNA]
CeRNA2RGS20[mRNA]
Tissue/Cell lineScc-9,Scc-25, Hn4, Tca-8113,Cal-27,Oscc Tissues
SpecieHomo sapiens (human)
CitationOncol Rep 2018 Apr 39, 1948-1956 doi:10.3892/or.2018.6283 PMID:29484420
Reference title
lncRNA NEAT1 promotes cell proliferation and invasion by regulating miR-365/RGS20 in oral squamous cell carcinoma.
Experimental verification
qPCR,Western blot,Luciferase reporter assay,in vitro knockdown etc
Functional description
Functionally,knockdown of NEAT1 significantly inhibited cell proliferation and invasion and induced cell cycle arrest at the G0/G1 phase and apoptosis, whereas inhibition of miR365 abolished the suppressive effect of NEAT1 knockdown on cellular processes.RGS20,a direct target of miR365,could reverse the tumor suppressive role of miR365 mimic by enhancing cell viability and motility.Moreover, the protein levels of RGS20, cyclin D1, Ecadherin, Ncadherin and vimentin could be regulated by the NEAT1/miR365 axis.NEAT1 silencing also inhibited tumor growth in vivo.NEAT1/miR365/RGS20 axis may be a novel mechanism or therapeutic strategy for OSCC treatment.
Annotations
External Annotation for NEAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
