Basic Information
Regular Relationship :
Tissue/Cell lineBgc823, Sgc-7901, Ags, Mgc803, Mkn28, Cell Lines
SpecieHomo sapiens (human)
CitationJ Cell Biochem 2019 Apr 120, 4827-4836 doi:10.1002/jcb.26691 PMID:29363783
Reference title
Long noncoding RNA NEAT1-modualted miR-506 regulates gastric cancer development through targeting STAT3.
Experimental verification
qRT-PCR,Western blot,Luciferase reporter assay,in vitro knockdown,RIP
Functional description
NEAT1 and STAT3 expression were significantly upregulated in human gastric cancer cells including BGC823, SGC-7901,AGS, MGC803 and MKN28 cells compared to normal gastric epithelial cells GES-1 while miR-506 was downregulated.the negative binding correlation between NEAT1 and miR-506. In addition, miR-506 can modulate expression of NEAT1 in vitro. STAT3 was predicted as an mRNA target of miR-506 and miR-506 mimics can suppress STAT3 mRNA expression.downregulation of NEAT1 can restrain gastric cancer development by decreasing STAT3 which can be reversed by miR-506 inhibitors.
Annotations
External Annotation for NEAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
