Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1NR2F1-AS1[LncRNA]
miRNAmiR-363[miRNA]
CeRNA2ABCC1[mRNA]
Tissue/Cell lineHuh7, Hepg2,Lo-2, Hcc Tissues
SpecieHomo sapiens (human)
CitationJ Cell Mol Med 2018 Jun 22, 3238-3245 doi:10.1111/jcmm.13605 PMID:29602203
Reference title
LncRNA NR2F1-AS1 regulates hepatocellular carcinoma oxaliplatin resistance by targeting ABCC1 via miR-363.
Experimental verification
qPCR,Microarray,Western blot etc
Functional description
miR-363 targeted the 3'-UTR of NR2F1-AS1 and ABCC1 mRNA,presenting that NR2F1-AS1 promoted ABCC1 expression through endogenous sponging miR-363.NR2F1-AS1 regulates HCC OXA resistance through targeting miR-363-ABCC1 pathway,providing a vital theoretic mechanism and therapeutic target for HCC chemoresistance.
Annotations
External Annotation for NR2F1-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
