Basic Information
Regular Relationship :
Tissue/Cell lineHuvec
SpecieHomo sapiens (human)
CitationInt J Mol Med 2018 Jul 42, 489-496 doi:10.3892/ijmm.2018.3595 PMID:29620147
Reference title
lncRNA PVT1 promotes the angiogenesis of vascular endothelial cell by targeting miR-26b to activate CTGF/ANGPT2.
Experimental verification
Western blot, Luciferase reporter assay etc
Functional description
PVT1 affected cell proliferation, migration and in vitro vascular tube formation of HUVECs. In addition,it was determined that PVT1 was able to bind and degrade miR26b to promote connective tissue growth factor (CTGF) and angiopoietin 2 (ANGPT2) expression.miR26b was also identified to have a suppressive role in cell proliferation,migration and in vitro vascular tube formation of HUVECs via binding 3'UTR regions and downregulating CTGF and ANGPT2 expression levels.PVT1 was important in angiogenesis of vascular endothelial cell as ceRNA to bind and degrade miR26b,which expanded the current understanding of PVT1 as ceRNA to regulate biological processes.
Annotations
External Annotation for PVT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
